Ocular tolerance to cyanoacrylate monomer tissue adhesive analogues.

Ocular tolerance to cyanoacrylate tissue adhesives was evaluated in rabbits. In the experimental studies, tissue adhesives were implanted intralamellarly, subconjunctivally, and in the anterior chamber. The eyes were examined clinically and histologically at different time intervals. In the cornea and conjunctiva, the adhesive reacted as any inert material. The reaction was considerably less than that to silk or catgut. In the anterior chamber, the reaction was moderate in most cases.